In terms of Artificial Intelligence I think we will see machine forms of intelligence that can outperform human intelligence in such a broad range of ways that they pose a threat. Humans will undoubtedly defer to such systems.
The challenge is to enhance human abilities more directly in order for humans to directly take on board such intelligence and become one with it. This involves a much better developed interface system between the human nervous system and silicon/technology. An interface system between humans and technology will enable humans to have improved memory and mathematical skills, an increased sensory range and the ability to communicate by thought alone.
From this point of view, the issues society should be addressing in the next 18 years are, the appropriate and increased use of electronic medicine (electronics rather than chemicals for both the treatment of ailments and improvement of health). Society should also consider tailoring and ethically accepting technical enhancements to humans.