The greatest innovation in my field of high-energy physics (which incorporates the two traditionally separate fields of particle physics and general relativity) is the discovery of the Standard Model of particle physics (which explains all phenomena not including gravity) and the discovery of a mathematically consistent theory of quantum gravity by Feynman and Weinberg. These two discoveries have given us a Theory of Everything (TOE), the greatest achievement of the human mind.
We have had this TOE for 30 years, but the vast majority of physicists will not admit it, because the TOE has implications they find philosophically unacceptable. Specifically, they refuse to accept the existence of the quantum multiverse, and the existence of the Cosmological Singularity. The existence of both is a fundamental and inescapable mathematical implication of the TOE.
I, on the other hand, accept both of these implications of the TOE.
Book Suggestions: The Physics of Christianity (buy this book from Amazon(UK))