In the field of cellular biology, the greatest invention was the development and refinement of the electron microscope. For the first time subcellular structures were identified, imaged and further investigated. While biochemistry and molecular biology have given us many advances, without being able to localise where particular reactions occurred or elements of DNA/RNA were found, the chemical information had limited usefulness. The potency of the combined information of both ‘what’ and ‘where’ have made possible many of the advances of modern biology, physiology and medicine.
Robert S Baratz is president of the National Council Against Health Fraud, and assistant clinical professor of medicine at Boston University School of Medicine.