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Scott Aaronson theoretical computer scientist at the Institute for Quantum Computing University of Waterloo, Canada The greatest innovation in computer science was to represent machines as nothing but strings of information. |
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Ian Abley architect and research engineer The brick made civilisation possible, and will continue to do so. |
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Professor Thomas M Addiscott soil scientist, computer modeller and science writer The Haber-Bosch process for the synthesis of ammonia allowing the production of nitrogen fertiliser. |
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Anjana Ahuja science columnist The Times Sanitation, vaccination and modern surgery are all worth celebrating. |
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Dr Hugh Aldersey-Williams writer and curator As a writer I find two of the greatest innovations to be the tea cosy and digestive biscuits. |
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Dr Roger Armour retired consultant surgeon and inventor of the Optyse Lens Free Ophthalmoscope When Helmholtz announced his invention of the ophthalmoscope in December 1850, he gave the healing professions a priceless gift which he refused to patent. |
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Branko R Babic inventor Modern life without electricity would be impossible and would return humanity to prehistoric modes of existence. |
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Dr Philip Ball consultant editor at Nature and science writer Arguably, the most useful innovations in chemistry are methods of chemical analysis. I know that this sounds almost irredeemably dull, but I can't help feeling that that is the way with truly useful innovations. |
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Michael Baum emeritus professor of surgery and visiting professor of medical humanities at University College London. Understanding breast cancer as a systemic disorder has led to better survival rates. |
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Gordon Bell principal researcher with the Microsoft eSciences Research Group, San Francisco The Big Bang occurred when processing, memory, and control (programming) all came together to create the stored program computer concept that was the basis of subsequent computer innovation. |
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Dr Jong Bhak director, Korean Bioinformation Center (KOBIC) Exchanging biological/scientific information via openfree hypertext servers will revolutionise the collaborative work of biology/science in the near future as much as the internet itself did to biology in the 1990s. |
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Dr Susan Blackmore writer, lecturer and broadcaster The electroencephalogram. It began the process of being able to peer inside a human brain and watch it actually working. |
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Bernhard Blauel architect, RIBA, Blauel Architects. The greatest innovation in my field is man’s ability to reach places where gravity is reduced to imperceptible levels. |
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Dr Sonja Boehmer-Christiansen reader in geography at the University of Hull I can think of a bad one: ever more people pontificate about science and especially 'global warming' without any real understanding of climate and how little we understand it. |
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David Bradley freelance science writer based in Cambridge, sciencebase.com Our knowledge of the inorganic chemistry of ammonia, lime and sulphuric acid. |
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Professor Vladimir Burdyuzha Astro Space Center, Lebedev Physical Institute, Moscow The discovery that dark energy was already boosting the expansion of the Universe as long as nine billion years ago. |
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Nick Bush business improvement consultant, BT Retail What makes the Internet a key innovation is the effect it is beginning to have on societal structures in business, politics and leisure. |
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Dr Marcus Chown cosmology consultant of New Scientist The greatest innovation in physics was the realisation that the fundamental reality that underpins the world is totally unlike the familiar, everyday world of our senses. |
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Dr Stuart Clark science journalist and author Changing the emphasis of astronomy from measuring stellar positions for navigation to investigating the physical nature of celestial objects. |
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Professor Peter Cochrane co-founder of ConceptLabs The invention of the triode vacuum tube in 1915 by Lee DeForest marks the beginning of the information technology revolution. |
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Phillip J Colquitt independent technical advisor The most important innovation I’ve seen, being involved in health care for 30 years, is the move from metal to plastic. |
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Quentin Cooper broadcaster Radio can bring you into instant contact with almost anyone on the planet in an unfettered unfiltered way |
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Dr Justin Dillon senior lecturer in science and environmental education and subject director, PGCE chemistry, King's College London In the field of science education, the Nuffield Foundation Science Teaching Project (1949-1993) stands head and shoulders above any other curriculum development. |
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Dr K Eric Drexler author The development of a method that enables the design and fabrication of 3D, million-atom-scale, atomically precise structures by one person in a single day. |
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Nicola Drury genetic counsellor The discovery of the double helix structure of DNA by Watson and Crick in 1953. |
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Marcus Du Sautoy professor of mathematics at Wadham College, Oxford The zeta function is a nineteenth century concept exploited by the German mathematician Bernhard Riemann to reveal many of the secrets of the primes. |
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Jack D Dunitz emeritus professor of chemical crystallography at the Swiss Federal Institute of Technology The discovery by Max von Laue in 1912 that X-rays are diffracted by crystals, and the application of this to determine the atomic arrangement within crystals. |
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John Dupre professor of philosophy of science, University of Exeter Seeing nature at all levels as dynamic and changing, as consisting only of processes and events rather than of things with eternally definable properties. |
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David Edgerton Hans Rausing professor in the Centre for the History of Science, Technology and Medicine Imperial College London. I don't know, and I don't think anyone else knows either! |
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Artur Ekert Leigh Trapnell professor of quantum physics, University of Cambridge In my field (quantum computing and cryptography) the great innovations are yet to come (but I am happy with my discovery of quantum cryptography). |
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Dr John Emsley chemist and science writer The discovery of elemental phosphorus by Hennig Brandt of Hamburg in 1669. |
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Edzard Ernst professor of complementary medicine, Peninsula Medical School, Universities of Exeter and Plymouth The controlled clinical trial changed medicine entirely as for the first time in history we were able to make formal comparisons and define what works and what doesn't work. |
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Dr Dylan Evans writer and independent social entrepeneur I can't think of a single innovation in any field, let alone my own, that merits the adjective ‘great’. |
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Nina Fedoroff Willaman professor of life sciences and Evan Pugh professor The greatest innovation in my field has been the ability to introduce genes into plants. |
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Stanley Feldman emeritus professor of anaesthesia Imperial College London Today we realise that life is impossible unless we control what Bernard described as the ‘milieur interieur’. It is the real secret of life.
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Dr Christine Finn archaeologist at the Universities of Bradford and Bristol The possibility of fast, efficient, public, and low-cost communications that span contexts and time-zones - the internet. |
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Edmond H Fischer professor emeritus of biochemistry at the University of Washington There is no question that the greatest advances occurred in the field of genetic engineering, with the cloning, characterisation, manipulation and expression of genes. |
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Professor Brian J Ford biologist, microscopist and science writer/broadcaster Microscopes reveal living universes of microbes, which you cannot otherwise know. |
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Ken Freeman Duffield professor, Research School of Astronomy & Astrophysics The Australian National University Because charge-coupled devices are linear, have a high quantum efficiency and cover a useful area, they transformed optical astronomy into the precise and quantitative field that we now enjoy.
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John Garrow emeritus professor of human nutrition University of London The greatest innovation in the field of human nutrition was the Human Calorimeter built by W O Atwater and F G Benedict in a basement room in the Wesleyan University, Middletown, Connecticut |
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Dr Adrian Gibbs virologist The single most important invention for understanding the evolution of viruses was gene sequencing, closely followed by computers |
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Dr Ian Gibson MP for Norwich North, ex-dean of the School of Biological Sciences, University of East Anglia The greatest innovation in my field was the PCR (polymerase chain reaction) process by which several sections of DNA could be multiplied many times accurately to give many copies. |
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Dr Kenneth Green resident scholar at the American Enterprise Institute The environmental movement of the 1970s raised awareness of the many harms that humans can do to the environment; Aaron Wildavsky created a rational framework for figuring out what to do about it.
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Clive Grinyer director of design, Orange France Telecom ExploCentre Text messaging, originally installed as a tool for engineers to repair or update phones, provided a fast, non-intrusive, secretive way of communicating that proved hugely popular. |
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John Hall University of Colorado at Boulder; winner, Nobel Prize for Physics, 2005 A new laser can be brought into the lab, unpacked, and measured accurately (how about 15 digits?) before lunch, and perhaps even before morning coffee time |
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Nick Hayward researcher in biophysics and the biology of neurodegenerative diseases at the University of Kuopio Magnetic resonance imaging (MRI) has accelerated the advancement of many fields of research |
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Dr Kerry Hempenstall Educational psychologist, senior lecturer in psychology at RMIT University in Melbourne When the alphabetic principle is understood, we can read and write any words that we can say, not only the words that we’ve seen before and managed to recognise |
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Dr Caspar JM Hewett chair of the Great Debate and environmental consultant The digital computer, which has enabled the mathematical modelling of complex processes. |
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Dr Sharon Ann Holgate freelance science writer and broadcaster I've often wondered if the scientists responsible for the transistor had even begun to imagine the scale and influence of the electronics industry that their breakthrough would spawn. |
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John Horgan Science writer and journalist, director of the Horganism Free will is the single most profound innovation in human intellectual history |
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Sir Tim Hunt Principal scientist, Cancer Research UK, Nobel Prize for Physiology or Medicine in 2001 (shared with Lee Hartwell and Paul Nurse) Recombinant DNA technology stands for a whole panoply of clever tricks and brilliant inventions that have earned their many originators scores (or at least dozens) of Nobel prizes |
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Piet Hut Professor of interdisciplinary studies at the Institute for Advanced Study The possibility of creating a virtual lab in which to let stars and galaxies interact with each other is the greatest qualitative innovation in astrophysics |
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Simon Ings science writer, critic and novelist The invention of spectacles with arms increased one's comfortable reading-time from a few minutes to virtually every waking moment, and drove the Enlightenment as surely as the invention of printing drove the Renaissance |
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Charles Kohlhase artist, science educator, and lead designer of numerous planetary missions Tremendous advances have been made in the art and science of deep space navigation. |
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Dr Boris Kotchoubey Researcher at the Institute of Medical Psychology and Behavioral Neurobiology at the University of Tübingen The greatest innovation in psychology would be to marry social science and the science of the brain |
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Dr Peter Lane veterinary surgeon When chloroform became available, it meant that a whole series of serious surgical operations, including cutting into body cavities, could be undertaken humanely |
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Graeme Laver Former professor of biochemistry and molecular biology at the Australian National University in Canberra The concept of preventing infection by viruses by administering killed or weakened preparations of viruses to people (and animals) has lead to the prevention and in some cases elimination, of many diseases caused by viruses. Smallpox, polio, yellow fever, measles and mumps are some that come to mind |
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William L Ledger Professor of obstetrics and gynaecology at the University of Sheffield It has to be the achievement of fertilisation 'in vitro' with successful embryo transfer and implantation leading to the birth of Louise Brown in 1978 |
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Dr Peggy G Lemaux Cooperative extension specialist in plant biotechnology at the University of California in Berkeley
Without a doubt, the invention of most impact in the field of biology - be it that of animals, micro-organisms or plants - is the development and use of recombinant DNA methods |
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Dr Gilbert V Levin Founder of Spherix Language makes possible the accumulation of knowledge, including science, and its transmission from generation to generation |
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Professor Norman Levitt Professor of mathematics at Rutgers University in New Jersey The new methods for analysing topological questions that arise from the study of Ricci flows on Riemannian structures, utilising deep ideas from differential geometry and partial differential equations |
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Sir Chris Llewellyn-Smith Director UKAEA Culham Tokamaks are the most promising route to mastering fusion (which powers the sun) on earth and thereby providing an essentially limitless, environmentally responsible, large scale source of energy |
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Professor Seth Lloyd Professor of quantum mechanical engineering MIT. The idea that we should think about the fundamental processes in physics in terms of information |
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Dr Bob Lucky Former corporate vice president of research at Telcordia Technologies The greatest innovation was the open platform for communications created by the Internet architecture |
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Professor Nils-Axel Mörner professor of paleogeophysics and geodynamics at Stockholm University When Nicolaus Copernicus in 1543 put the Sun in the centre, a depressing ‘ruling model’ was killed after 1800 years, and science, thinking and innovation exploded. |
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Ken MacLeod science fiction author The greatest innovation in my field was the infodump, otherwise known as the expository lump... |
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