I should teach the world the following. First, observe, observe, observe, as often as possible. Second, measure/monitor parameters as often as possible and as accurately as possible, with whatever measuring device available. Third, document all observations/measurements meticulously and frequently, and look for emerging patterns of change.

Fourth, it is very likely that similar occurrences have been documented or reported previously. But is there a reasonably plausible alternative explanation for the changes that have taken place, or for the changes that are likely to occur? Fifth, it is necessary to spend time - a long time, invariably - providing an acceptable alternative. This would hopefully provide a better understanding, and better management of similar occurrences.

Lakshman Karalliedde is coeditor of Organophosphates and Health (buy this book from Amazon (UK) or Amazon (USA)), and the Handbook of Drug Interactions (buy this book from Amazon (UK) or Amazon (USA)).